Paulo Roberto Ribeiro Costa

Prof. Paulo R. R. Costa

Bolsista de Produtividade 1B, Fator H = 23

 

Publicações recentes:

  1. RUMJANEK, V. M ; MAIA, RAQUEL C ; SALUSTIANO, EDUARDO J ; COSTA, P.R.R.. Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-Tumor Activity against MDR Leukemias. Anti-Cancer Agents in Medicinal Chemistry, v. 18, p. 00, 2019. Sem alunos do IPPN.

 

  1. MENDES, JOSEANE A. ; MERINO, PEDRO ; SOLER, TATIANA ; Salustiano, Eduardo J. ; COSTA, PAULO R. R.; YUS, MIGUEL ; FOUBELO, FRANCISCO ; BUARQUE, CAMILLA D. . Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias. JOURNAL OF ORGANIC CHEMISTRY, v. 84, p. 2219-2233, 2019. Sem alunos do IPPN. Doutoranda da Camilla, PUC.

 

  1. STRAUCH, MARCELO A. ; TOMAZ, MARCELO AMORIM ; MONTEIRO-MACHADO, MARCOS ; CONS, BRUNO LEMOS ; PATRÃO-NETO, FERNANDO CHAGAS ; TEIXEIRA-CRUZ, JHONATHA DA MOTA ; TAVARES-HENRIQUES, MATHEUS DA SILVA ; NOGUEIRA-SOUZA, PÂMELLA DOURILA ; GOMES, SARA L. S. ; COSTA, PAULO R. R.; SCHAEFFER, EDGAR ; DA SILVA, ALCIDES J. M. ; MELO, PAULO A. . Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms. PLoS One, v. 14, p. e0211229, 2019. Sem alunos do IPPN. Alunos do PFQM-ICB do Prof. Paulo Melo

 

  1. SOUZA, LUANA G. ; DE O. DOMINGOS, JORGE L. ; DE A. FERNANDES, TALITA ; RENNO, MAGDALENA N. ; SANSANO, JOSE M. ; NAJERA, CARMEN ; COSTA, PAULO R.R.. Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of N-fluoroammonium salts of cinchonine. JOURNAL OF FLUORINE CHEMISTRY, v. 217, p. 72-79, 2019. Doutoranda IPPN

 

  1. CALEFFI, GUILHERME S. ; LARRAÑAGA, OLATZ ; FERRÁNDIZ-SAPERAS, MARCOS ; COSTA, PAULO R. R.; NÁJERA, CARMEN ; DE CÓZAR, ABEL ; COSSÍO, FERNANDO P. ; SANSANO, JOSÉ M. . Switching Diastereoselectivity in Catalytic Enantioselective (3+2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos-Derived Ligands. JOURNAL OF ORGANIC CHEMISTRY, v. 84, p. 10593-10605, 2019. Doutorando IPPN

 

  1. MARTINO, THIAGO; KUDROLLI, TARANA A. ; KUMAR, BINOD ; SALVIANO, ISIS ; MENCALHA, ANDRÉ ; COELHO, MARSEN GARCIA P. ; JUSTO, GRAÇA ; COSTA, PAULO R. RIBEIRO; SABINO, KÁTIA C. CARVALHO ; LUPOLD, SHAWN E. . The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress. PROSTATE, v. 78, p. 140-151, 2018. Sem alunos do IPPN. Aluno de doutorado do IB-UERJ, da Profa. Katia Sabino

 

  1. LEÃO, RAQUEL A.C. ; PINHO, VAGNER D. ; COELHO, ARTUR S. ; KÜMMERLE, ARTHUR E. ; COSTA, PAULO R.R.. New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations. ANAIS DA ACADEMIA BRASILEIRA DE CIÊNCIAS (ONLINE), v. 90, p. 1273-1278, 2018. Sem alunos do IPPN. Raquel, ex-pos-doc, Vagner, ex-mestrando

 

  1. FAIÕES, VIVIANE DOS SANTOS ; DA FROTA, LÍVIA C. R. M. ; CUNHA-JUNIOR, EDÉZIO FERREIRA ; BARCELLOS, JULIO C. F. ; DA SILVA, THAYSSA ; NETTO, CHAQUIP DAHER ; DA-SILVA, SILVIA AMARAL GONÇALVES ; DA SILVA, ALCIDES J. M. ; COSTA, PAULO R. R.; TORRES-SANTOS, EDUARDO CAIO . Second-generation pterocarpanquinones: synthesis and antileishmanial activity. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, v. 24, p. 35, 2018. Sem alunos do IPPN. Alunos do Caio, FIOCRUZ

 

  1. MENDES, JOSEANE A. ; Salustiano, E.J. ; PIRES, CARULINI DE S. ; OLIVEIRA, THAÍS ; BARCELLOS, JULIO C.F. ; CIFUENTES, JHONNY M.C. ; COSTA, P.R.R.; RENNÓ, MAGDALENA N. ; Buarque, Camilla D. . 11a-N-tosyl-5-carbapterocarpans: synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties. BIOORGANIC CHEMISTRY, v. 80, p. 585-590, 2018. Doutorando IPPN

 

  1. COSTA, P.R.R. xxxxxxxx. Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Alemanha, v. 96, p. 223-233, 2017. Citações:5|4. Sem alunos do IPPN.

 

  1. SCATENA, GABRIEL S. ; CASSIANO, NEILA M. ; NETTO, CHAQUIP D.; COSTA, PAULO R.R.; CASS, QUEZIA B. ; BATISTA, JOÃO M. . Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB-118. CHIRALITY, v. 29, p. 167-171, 2017. Sem alunos do IPPN.

 

  1. CUPELLO, MAURICIO PEIXOTO ; SARAIVA, FRANCIS MONIQUE ; IPPOLITO, PEDRO ; FERNANDES, ANDRÉIA DA SILVA ; MENNA-BARRETO, RUBEM FIGUEIREDO SADOKO ; COSTA, DEBORA DE SOUSA DOS SANTOS ; PAULA, JESSICA ISIS OLIVEIRA ; COSTA, PAULO ROBERTO RIBEIRO; NOGUEIRA, NATÁLIA PEREIRA ; FELZENSWALB, ISRAEL ; DIAS, AYRES GUIMARÃES ; PAES, MARCIA CRISTINA . Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative. Biomed Research International, v. 2017, p. 1-8, 2017. Citações:2|2. Sem alunos do IPPN.

 

  1. COSTA, PAULO; CÍVICOS, JOSÉ ; COIMBRA, JULIANA . Solvent-Free Synthesis of Salen Ligands and Pd(II)- and Cu(II)-Salen Complexes: Their Use in the Oxidation of α-Tetralones to α-Naphthols. SYNTHESIS-STUTTGART, v. 49, p. A-1, 2017. Pós-doc CAPES no meu laboratório

 

  1. CÍVICOS, JOSÉ ; COSTA, PAULO; DOMINGOS, JORGE . Palladium-Catalyzed α-Arylation of Dimethyl Malonate and Ethyl Cyanoacetate with o-Alkoxybromobenzenes for the Synthesis of Phenylacetic Acid, Esters and Phenylacetonitriles. SynOpen, v. 01, p. 0091-0096, 2017. Pós-doc CAPES no meu laboratório

 

  1. FERNANDES, TALITA DE A. ; VIZCAÍNO-MILLA, PASCUALA ; RAVASCO, JOÃO M.J.M. ; ORTEGA-MARTÍNEZ, AITOR ; SANSANO, JOSÉ M. ; NÁJERA, CARMEN ; COSTA, PAULO R.R.; FISER, BÉLA ; GÓMEZ-BENGOA, ENRIQUE . Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes. Tetrahedron: Asymmetry (Print), v. 27, p. 118-122, 2016. Citações:2|9. Pós-doc FAPERJ no meu laboratório

 

  1. FERNANDES, TALITA DE A. ; MANVAR, DINESH ; DOMINGOS, JORGE L.O. ; BASU, AMARTYA ; NICHOLS, DANIEL BRIAN ; KAUSHIK-BASU, NEERJA ; COSTA, PAULO R.R.. 5-Carba-pterocarpens: A New Scaffold with Anti-HCV Activity. European Journal of Medicinal Chemistry, v. 112, p. 33-38, 2016. Citações:2|3 Pós-doc FAPERJ no meu laboratório

 

  1. CUNHA-JUNIOR, E. F. ; MARTINS, T. M. ; CANTO-CAVALHEIRO, M. M. ; MARQUES, P. R. ; PORTARI, E. A. ; COELHO, M. G. P. ; NETTO, C. D. ; COSTA, P.R.R.; SABINO, K. C. C. ; TORRES-SANTOS, E. C. . Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 60, p. 3794-3801, 2016. Citações:1|5. Sem alunos do IPPN. Alunos do Caio, FIOCRUZ

 

  1. ANDRADE-NETO, VALTER VIANA ; CUNHA-JÚNIOR, EDÉZIO FERREIRA ; CANTO-CAVALHEIRO, MARILENE MARCUZZO DO ; ATELLA, GEÓRGIA CORREA ; FERNANDES, TALITA DE ALMEIDA ; COSTA, PAULO ROBERTO RIBEIRO; TORRES-SANTOS, EDUARDO CAIO . Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In VitroSynergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 60, p. 6844-6852, 2016. Pós-doc FAPERJ no meu laboratório

 

  1. SALUSTIANO, EDUARDO J.; DUMAS, MATHEUS L. ; SILVA-SANTOS, GABRIEL G. ; NETTO, CHAQUIP D.; COSTA, PAULO R. R. ; RUMJANEK, VIVIAN M. . In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118. INVESTIGATIONAL NEW DRUGS, v. 34, p. 541-551, 2016. Sem alunos do IPPN. Alunos da Vivian, IBqM-ICB

 

  1. SILVA, THAISSA L. ; FERREIRA, FABRICIA R. ; DE’VASCONCELOS, CAMILA C. ; DA’SILVA, ROSANNY CHRISTHINNY ; LIMA, DIMAS JOSÉ DA P. ; COSTA, PAULO R. R.; NETTO, CHAQUIP D.; GOULART, MARÍLIA O. F. . Reactive Oxygen Species Release, Alkylating Ability, and DNA Interactions of a Pterocarpanquinone: A Test Case for Electrochemistry. ChemElectroChem, v. 3, p. 2252-2263, 2016. Sem alunos do IPPN. Alunos da Marília Goulart-Maceio

 

  1. RIÇA, INGRED G. ; NETTO, CHAQUIP D.; RENNÓ, MAGDALENA N. ; ABREU, PAULA A. ; COSTA, PAULO R.R.; DA SILVA, ALCIDES J.M. ; CAVALCANTE, MOISÉS C.M. . Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice. BIOORGANIC & MEDICINAL CHEMISTRY, v. 24, p. 4415-4423, 2016. Sem alunos do IPPN. Aluna da Biofísica, ICB

 

  1. BARCELLOS, JULIO C.F. ; VILELA, GUILHERME V.M. DE A. ; BORGES, BEATRIZ H.F. ; MIRANDA, MARIA F.F. ; DIAS, AYRES G.; COSTA, PAULO R.R.. The syn-selective conjugate addition of amines to enoates derived from d-mannitol. TETRAHEDRON-ASYMMETRY, v. 27, p. 773-776, 2016. Doutorando IPPN

 

  1. CÍVICOS, JOSÉ F. ; ROCHA, CARLOS M. ; COSTA, PAULO R.R.; NÁJERA, CARMEN . Copper-versus palladium-catalyzed aromatization of 2-(methoxycarbonyl) tetralones: synthesis of methyl 1-hydroxy-2-naphthoates. TETRAHEDRON, v. 72, p. 1897-1902, 2016. Pós-Doutorado IPPN – CAPES

 

  1. ALVES, M. A. ; NIRMA, C. ; MOREIRA, M. M. ; SOARES, R. O. ; PASCUTTI, P. G. ; NOËL, F. ; COSTA, P. R. R.; SANT’ANNA, C. M. R. ; Barreiro, E. J.; LIMA, L. M. ; TINOCO, L. W. . Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery. RSC Advances, v. 6, p. 87738-87744, 2016. Citações:1|1. Sem alunos do IPPN. Alunos do Eliezer-Lídia-PFQM-ICB

 

  1. MANVAR, DINESH ; FERNANDES, TALITA DE A. ; DOMINGOS, JORGE L.O. ; BALJINNYAM, ERDENECHIMEG ; BASU, AMARTYA ; JUNIOR, EURIDES F.T. ; COSTA, PAULO R.R.; KAUSHIK-BASU, NEERJA . Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors. European Journal of Medicinal Chemistry, v. 93, p. 51-54, 2015. Citações:8|3. Pós-Doutorado IPPN – FAPERJ

 

  1. DE FARIA, FERNANDA ; BENTO LEAL, MARIA ; BERNARDO, PAULA ; COSTA, PAULO; MAIA, RAQUEL. NFκB Pathway and microRNA-9 and -21 are Involved in Sensitivity to the Pterocarpanquinone LQB-118 in Different CML Cell Lines. Anti-Cancer Agents in Medicinal Chemistry, v. 15, p. 345-352, 2015. Citações:3|4. Sem alunos do IPPN. Alunos da Raquel Maia – INCA-RJ

 

  1. BUARQUE, CAMILLA ; DOMINGOS, JORGE ; NETTO, CHAQUIP ; COSTA, PAULO. Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues. Current Organic Synthesis, v. 12, p. 772-794, 2015. Citações:1|3. Sem alunos.

 

  1. SILVA, KARINA LANI ; SOUZA, PALOMA SILVA DE ; COSTA, PAULO R.R.; MAIA, RAQUEL CIUVALSCHI . Abstract A51: Antineoplastic activity of novel synthetic compound pterocarpanquinone LQB-118 in lung cancer cells. Clinical Cancer Research (Print), v. 21, p. A51-A51, 2015. Citações:1. Sem alunos do IPPN. Alunos da Raquel Maia – INCA-RJ

 

  1. REIS, FLAVIANA RUADE DE SOUZA ; MORORÓ, JANIO DA SILVA ; SILVA, KARINA LANI ; BUARQUE, CAMILA D. ; COSTA, PAULO R.R; MAIA, RAQUEL CIUVALSCHI . Abstract A49: Efficiency of 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) in a panel of myeloid leukemia cell lines with different chemoresistance backgrounds. Clinical Cancer Research (Print), v. 21, p. A49-A49, 2015. Sem alunos do IPPN. Alunos da Raquel Maia – INCA-RJ

 

  1. COSTA, DÉBORA S.S. ; MARTINO, THIAGO; MAGALHÃES, FERNANDA C. ; JUSTO, GRAÇA ; COELHO, MARSEN G.P.; BARCELLOS, JULIO C.F. ; MOURA, VICTOR B. ; COSTA, PAULO R.R. ; SABINO, KÁTIA C.C. ; DIAS, AYRES G. . Synthesis of N-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines. Bioorganic & Medicinal Chemistry (Print), v. 23, p. 2053-2061, 2015. Citações:2|4. Mestranda-IPPN

 

  1. COSTA, PAULO R. R.; SANSANO, JOSÉ M. ; COSSÍO, UNAI ; BARCELLOS, JULIO C. F. ; DIAS, AYRES G.; NÁJERA, CARMEN ; ARRIETA, ANA ; DE CÓZAR, ABEL ; COSSÍO, FERNANDO P. . Synthesis of Chromen[4,3- b]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol. European Journal of Organic Chemistry (Print), v. 2015, p. 4689-4698, 2015. Citações:5|5. Doutorando IPPN

 

  1. BUARQUE, CAMILLA ; COSTA, PAULO; DIAS, AYRES ; BARCELLOS, JULIO ; BORGES, BEATRIZ ; MENDES, JOSEANE ; CERON, MAURICIO . Synthesis of 11a-N-Arylsulfonyl-5-carbapterocarpans (Tetrahydro-5H-benzo[a]carbazoles) by Azaarylation of Dihydronaphthalenes with o-Iodo-N-(Arylsulfonyl)anilines in Poly(ethylene glycol). Synthesis (Stuttgart), v. 47, p. 3013-3019, 2015. Citações:1|1. Doutorando IPPN

 

  1. COSTA, PAULO; DE MORAES, PAULA ; GASPAR, FRANCISCO ; BORGES, RACKEL ; NETTO, CHAQUIP ; LEÃO, RAQUEL ; NÁJERA, CARMEN . Ligand-Free Palladium-Catalyzed Oxyarylation of Dihydronaphthal­enes and Chromenequinone with o-Iodophenols and 3-Iodolawsone in PEG-400: An Efficient Synthesis of 5-Carbapterocarpans and Pterocarpanquinones. Synthesis (Stuttgart), v. 47, p. 3505-3512, 2015. Citações:3|5. Doutoranda IPPN – Mestrando IPPN

 

  1. DA SILVA, LUCIANA LEMOS RANGEL ; PORTES, JULIANA DE ARAUJO ; DE ARAÚJO, MARLON HEGGDORNE ; SANT’ANA SILVA, JÉSSICA LAYS ; RENNÓ, MAGDALENA NASCIMENTO ; NETTO, CHAQUIP DAHER ; DA SILVA, ALCIDES JOSÉ MONTEIRO ; COSTA, PAULO ROBERTO RIBEIRO; DE SOUZA, WANDERLEY ; SEABRA, SERGIO HENRIQUE ; DAMATTA, RENATO AUGUSTO . Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro. Parasitology International (Print), v. 64, p. 622-631, 2015. Citações:2|4. Sem alunos do IPPN.

 

  1. FERNANDES, TALITA DE A. ; DOMINGOS, JORGE L. O.; DA ROCHA, LUIZA I. A. ; DE MEDEIROS, SABRINA ; NÁJERA, CARMEN ; COSTA, PAULO R. R.. Synthesis of 5-Carbapterocarpens by α-Arylation of Tetralones Followed by One-Pot Demethylation/Cyclization with BBr3. European Journal of Organic Chemistry (Print), v. 2014, p. 1314-1320, 2014. Citações:4|5. Pós-Doutorado IPPN – FAPERJ

 

  1. BUARQUE, CAMILLA D. ; SALUSTIANO, EDUARDO J.; FRAGA, KEVIN C. ; ALVES, BRUNA R.M. ; COSTA, PAULO R.R.. 11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines. European Journal of Medicinal Chemistry, v. 78, p. 190-197, 2014. Citações:6|6. Sem alunos do IPPN. Alunos da Camilla, PUC.

 

  1. NESTAL DE MORAES, GABRIELA ; CASTRO, CAROLINA; SALUSTIANO, EDUARDO; DUMAS, MATHEUS ; COSTAS, FERNANDA ; LAM, ERIC ; COSTA, PAULO ; MAIA, RAQUEL . The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. International Journal of Oncology, v. 45, p. 1949-1958, 2014. Citações:7|7. Sem alunos do IPPN. Alunos da Raquel Maia, INCA-UFRJ.

 

  1. COSTA, LUCIANA ; PINHEIRO, ROBERTA O. ; DUTRA, PATRÍCIA M. L. ; SANTOS, ROSIANE F. ; CUNHA-JÚNIOR, EDÉZIO F. ; TORRES-SANTOS, EDUARDO C.; DA SILVA, ALCIDES J. M. ; COSTA, PAULO R. R.; DA-SILVA, SILVIA A. G. . Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters. Plos One, v. 9, p. e109672, 2014. Citações:1. Sem alunos do IPPN. Alunos Caio, FIOCRUZ.

 

  1. CORTOPASSI, WILIAN A.; PENNA-COUTINHO, JULIA ; AGUIAR, ANNA C. C. ; PIMENTEL, ANDRÉ S.; BUARQUE, CAMILLA D. ; COSTA, PAULO R. R. ; ALVES, BRUNA R. M. ; FRANÇA, TANOS C. C. ; KRETTLI, ANTONIANA U. . Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum. Plos One, v. 9, p. e91191, 2014. Citações:4|4. Sem alunos do IPPN.

 

  1. MARTINO, THIAGO; MAGALHÃES, FERNANDA C.J.; JUSTO, GRAÇA A. ; COELHO, MARSEN G.P. ; NETTO, CHAQUIP D. ; COSTA, PAULO R.R. ; SABINO, KÁTIA C.C. . The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression. Bioorganic & Medicinal Chemistry (Print), v. 22, p. 3115-3122, 2014. Citações:6|9. Sem alunos do IPPN. Mestrando da Katia Sabino-UERJ

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